Professor Andrea O'Connor

  • Room: Level: GR Room: G01
  • Building: Chemical Engineering #2
  • Campus: Parkville

Research interests

  • 3D printing
  • Antimicrobial materials
  • Biofilms
  • Biomaterials (Biodegradable materials, scaffolds, hydrogels)
  • Medical devices (Implants)
  • Tissue engineering

Personal webpage

http://www.bme.unimelb.edu.au/tissue-engineering/

Biography

Associate Professor O'Connor is the Deputy Head of the School of Chemical and Biomedical Engineering. Her expertise is in chemical and biomedical engineering with particular focus areas including biomaterials, tissue engineering, porous materials and downstream processing for biotechnology. She leads the Tissue Engineering Research Group in the Department of Biomedical Engineering.

Her research and teaching are focused in cross disciplinary applications of engineering involving biological systems, including a strong interest in 3D soft tissue engineering. She has active collaborations with several medical research institutes and medical device companies in Australia and has worked in the chemical industry in Australia and overseas.

Current Research Activities include:
Nano and Biomolecular Engineering - Tissue engineering Nanostructured materials
Bioprocess Engineering - Separations technology 3D printing

Recent publications

  1. O'Connell C, Onofrillo C, Duchi S, Li X, Zhang Y, Tian P, Lu L, Trengove A, Quigley A, Gambhir S, Khansari A, Mladenovska T, O'Connor A, Di Bella C, Choong P, Wallace G. Evaluation of sterilisation methods for bio-ink components: gelatin, gelatin methacryloyl, hyaluronic acid and hyaluronic acid methacryloyl. BIOFABRICATION. Institute of Physics Publishing. 2019, Vol. 11, Issue 3. DOI: 10.1088/1758-5090/ab0b7c
  2. Shakouri-Motlagh A, O'Connor A, Kalionis B, Heath D. Improved ex vivo expansion of mesenchymal stem cells on solubilized acellular fetal membranes. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A. Wiley-Liss. 2019, Vol. 107, Issue 1. DOI: 10.1002/jbm.a.36557
  3. Jafari J, Han X-L, Palmer J, Tran P, O'Connor A. Remote Control in Formation of 3D Multicellular Assemblies Using Magnetic Forces. ACS BIOMATERIALS SCIENCE & ENGINEERING. American Chemical Society. 2019, Vol. 5, Issue 5. DOI: 10.1021/acsbiomaterials.9b00297
  4. Atran P, O'Brien-Simpson N, Palmer J, Bock N, Reynolds E, Webster TJ, Deva A, Morrison W, O'Connor A. Selenium nanoparticles as anti-infective implant coatings for trauma orthopedics against methicillin-resistant Staphylococcus aureus and epidermidis: in vitro and in vivo assessment. INTERNATIONAL JOURNAL OF NANOMEDICINE. Dove Medical Press. 2019, Vol. 14. DOI: 10.2147/IJN.S197737
  5. Karimi F, Thombare V, Hutton C, O'Connor A, Qiao G, Heath D. Beyond RGD; nanoclusters of syndecan- and integrin-binding ligands synergistically enhance cell/material interactions. BIOMATERIALS. Elsevier Science. 2018, Vol. 187. DOI: 10.1016/j.biomaterials.2018.10.002
  6. Onofrillo C, Duchi S, O'Connell C, Blanchard R, O'Connor A, Scott M, Wallace G, Choong P, Di Bella C. Biofabrication of human articular cartilage: a path towards the development of a clinical treatment. BIOFABRICATION. Institute of Physics Publishing. 2018, Vol. 10, Issue 4. DOI: 10.1088/1758-5090/aad8d9
  7. Biswas D, O'Brien-Simpson N, Reynolds E, O'Connor A, Tran P. Comparative study of novel in situ decorated porous chitosan-selenium scaffolds and porous chitosan-silver scaffolds towards antimicrobial wound dressing application. JOURNAL OF COLLOID AND INTERFACE SCIENCE. Academic Press. 2018, Vol. 515. DOI: 10.1016/j.jcis.2018.01.007
  8. Karimi F, O'Connor A, Qiao G, Heath D. Integrin Clustering Matters: A Review of Biomaterials Functionalized with Multivalent Integrin-Binding Ligands to Improve Cell Adhesion, Migration, Differentiation, Angiogenesis, and Biomedical Device Integration. ADVANCED HEALTHCARE MATERIALS. Wiley - V C H Verlag GmbH & Co. KGaA. 2018, Vol. 7, Issue 12. DOI: 10.1002/adhm.201701324
  9. Herson MR, Hamilton K, White J, Alexander D, Poniatowski S, O'Connor A, Werkmeister JA. Interaction of preservation methods and radiation sterilization in human skin processing, with particular insight on the impact of the final water content and collagen disruption. Part I: process validation, water activity and collagen changes in tissues cryopreserved or processed using 50, 85 or 98% glycerol solutions. CELL AND TISSUE BANKING. Springer Verlag. 2018, Vol. 19, Issue 2. DOI: 10.1007/s10561-018-9694-1
  10. Gu D, Tan S, O'Connor A, Qiao G. On-Demand Cascade Release of Hydrophobic Chemotherapeutics from a Multicomponent Hydrogel System. ACS BIOMATERIALS SCIENCE & ENGINEERING. American Chemical Society. 2018, Vol. 4, Issue 5. DOI: 10.1021/acsbiomaterials.8b00166
  11. Kusuma G, Yang M, Brennecke S, O'Connor A, Kalionis B, Heath D. Transferable Matrixes Produced from Decellularized Extracellular Matrix Promote Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells and Facilitate Scale-Up. ACS BIOMATERIALS SCIENCE & ENGINEERING. American Chemical Society. 2018, Vol. 4, Issue 5. DOI: 10.1021/acsbiomaterials.7b00747
  12. Biswas D, Tran P, Tallon Galdeano C, O'Connor A. Combining mechanical foaming and thermally induced phase separation to generate chitosan scaffolds for soft tissue engineering. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION. VSP. 2017, Vol. 28, Issue 2. DOI: 10.1080/09205063.2016.1262164
  13. Kusuma G, Brennecke S, O'Connor A, Kalionis B, Heath D. Decellularized extracellular matrices produced from immortal cell lines derived from different parts of the placenta support primary mesenchymal stem cell expansion. PLOS ONE. Public Library of Science. 2017, Vol. 12, Issue 2. DOI: 10.1371/journal.pone.0171488
  14. Gu D, Tan S, Xu C, O'Connor A, Qiao G. Engineering tough, highly compressible, biodegradable hydrogels by tuning the network architecture. CHEMICAL COMMUNICATIONS. Royal Society of Chemistry. 2017, Vol. 53, Issue 50. DOI: 10.1039/c7cc02811c
  15. Gu D, O'Connor A, Qiao G, Ladewig K. Hydrogels with smart systems for delivery of hydrophobic drugs. EXPERT OPINION ON DRUG DELIVERY. Informa Healthcare. 2017, Vol. 14, Issue 7. DOI: 10.1080/17425247.2017.1245290

View a full list of publications on the University of Melbourne’s ‘Find An Expert’ profile