Dr Michelle De Silva

  • Room: Level: 01 Room: 121
  • Building: Chemical Engineering #2
  • Campus: Parkville

Research interests

  • Molecular biology, molecular genetics

Personal webpage



Michelle de Silva is the Centre Manager of the Particulate Fluids Processing Centre (PFPC) an Australian Research Council Special Research Centre at the University of Melbourne. The PFPC brings together internationally renowned researchers to form one of the world's leading multidisciplinary research centres in interfacial science and engineering. The research programs within the PFPC pioneer understanding of the interactions at the interfaces between particles and the fluids within which they are dispersed. The PFPC encompasses staff and students from across the Departments of Chemical and Biomolecular Engineering and Mathematics and Statistics along with the School of Chemistry and consists of approximately 25 senior academic staff, 45 research staff and 100 postgraduate students.

Michelle has a Bachelor of Science with majors in Genetics and Biochemistry and a PhD in Molecular Genetics. She has more than ten years of experience working as a medical researcher performing experimental research in the areas of gene discovery for attention deficit hyperactivity disorder and cell regeneration therapies for hearing loss and heart disease.

Recent publications

  1. Nayagam B, Rickard N, De Silva M, Shepherd R. A protocol for cryoembedding the adult guinea pig cochlea for fluorescence immunohistology. Journal of Neuroscience Methods. Elsevier Science. 2009, Vol. 176. DOI: 10.1016/j.jneumeth.2008.09.007
  2. Hildebrand M, Newton, Gubbels, Sheffield, Kochhar, De Silva M, Dahl H, Rose, Behlke, Smith. Advances in Molecular and Cellular Therapies for Hearing Loss. Molecular Therapy. Nature Publishing Group. 2008, Vol. 16, Issue 2. DOI: 10.1038/sj.mt.6300351
  3. Nayagam B, De Silva M, Shepherd R. Concise Review: The Potential of Stem Cells for Auditory Neuron Generation and Replacement. Stem Cells. AlphaMed Press. 2007, Vol. 25, Issue 11. DOI: 10.1634/stemcells.2007-0393
  4. Hildebrand M, De Silva M, Klockars, Campbell A, Smith, Dahl H. Gene expression profiling analysis of the inner ear. Hearing Research. Elsevier Science. 2007, Vol. 225, Issue 1-2.
  5. Hildebrand M, De Silva M, Tan T, Rose, Nishimura, Tolmachova, Hulett M, White S, Silver J, Bahlo M, Smith JH, Dahl H. Molecular Characterization of a Novel X-Linked Syndrome Involving Developmental Delay and Deafness. American Journal of Medical Genetics. Wiley-Liss. 2007, Vol. 143A. DOI: 10.1002/ajmg.a.31995
  6. Hildebrand M, De Silva M, Gardner R, Rose E, De Graaf E, Bahlo M, Dahl H. Cochlear implants for DFNA17 deafness. Laryngoscope. Lippincott Williams & Wilkins. 2006, Vol. 116, Issue 12. DOI: 10.1097/01.mlg.0000242089.72880.f8
  7. Nayagam B, Hardman J, De Silva M, Epp S, Coco A, Crook J, Shepherd R. Fate of embryonic stem cells transplanted into the deafened mammalian cochlea. Cell Transplantation. Cognizant Communication Corporation. 2006, Vol. 15, Issue 5. DOI: 10.3727/000000006783981819
  8. Dahl H, Manji SM, De Silva M, Peverelli M, Hildebrand M. Genetic aspects of hearing loss. Acoustics Australia. Cronulla Printing Co. 2006, Vol. 34, Issue 1.
  9. Nayagam B, Backhouse SS, Coco A, De Silva M, Shepherd R. Hydrogel for cell encapsulation in the deafened mammalian cochlea. 7th International Academic Conference of Immunobiology in Orhinolaryngology. 2006.
  10. Shepherd R, Nayagam B, Backhouse SS, De Silva M, Coco A. Indications for using genes or cells to regenerate the ear. 7th International Academic Conference of Immunobiology in Otorhinolaryngology. 2006.
  11. Harikrishnan, Pal, Yarski, Baker K, Chow Z, De Silva M, Okabe, Wang, Jones L, Sif, El-Osta A. Testing for association between MeCP2 and the brahma-associated SWI/SNF chromatin-remodeling complex. Nature Genetics. Nature America. 2006, Vol. 38, Issue 9. DOI: 10.1038/ng0906-964
  12. Hildebrand MS, Dahl HM, Hardman J, Nayagam B, Shepherd R, De Silva M. A novel surgical approach for delivery of mouse ES cells into the scala media of the adult guinea pig cochlea. International Society for Stem Cell Research. 2005.
  13. Nayagam B, Hardman J, De Silva M, Crook J, Shepherd R. Strategies for stem cell based therapy in the mammalian cochlea. International Society for Stem Cell Research. 2005.
  14. Hildebrand M, Dahl H, Hardman J, Nayagam B, Shepherd R, De Silva M. Survival of partially differentiated mouse embryonic stem cells in the scala media of the guinea pig cochlea.. Journal of the Association for Research in Otolaryngology. Springer Verlag. 2005, Vol. 6. DOI: 10.1007/s10162-005-0012-9
  15. Nayagam B, Hardman J, Crook J, De Silva M, Epp S, Coco A, Shepherd R. Survival and migration of partially defferentiated stem cells in the deafened guinea pig cochlea. Frontiers in Otorhinolaryngology. 2004.

View a full list of publications on the University of Melbourne’s ‘Find An Expert’ profile